Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1

Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1

Occurrence of cisplatin-resistance in bladder cancer is frequent and results in disease progression. Thus, novel therapeutic approaches are a high medical need for patients suffering from chemotherapy failure. The purpose of this study was to test the combination of the DNA methyltransferase inhibit...

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Bibliographic Details
Main Authors: Chenyin Wang, Alexandra Hamacher, Patrick Petzsch, Karl Köhrer, Günter Niegisch, Michèle J. Hoffmann, Wolfgang A. Schulz, Matthias U. Kassack
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
bladder cancer
cisplatin
dna methyltransferase inhibitor
drug combination study
histone deacetylase inhibitor
forkhead box class o1
Online Access:https://www.mdpi.com/2072-6694/12/2/337

Internet

https://www.mdpi.com/2072-6694/12/2/337

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