Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function

Simultaneous Activation of Erk1/2 and Akt Signaling is Critical for Formononetin-Induced Promotion of Endothelial Function

Formononetin (FMNT) is a major bioactive compound from Astragalus membranaceus (Fisch.) Bunge, and has been widely used to treat conditions related to vascular insufficiency. However, the molecular mechanism for the therapeutic effect has not been well defined. This study aimed to investigate the ef...

Full description

Bibliographic Details
Main Authors: Jinjun Wu, Muyan Kong, Yanmei Lou, Leyan Li, Chunlin Yang, Huifang Xu, Yuqi Cui, Hong Hao, Zhenguo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
formononetin
angiogenesis
ERK1/2
Akt
eNOS
NO
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.608518/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.608518/full

Similar Items