A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity

A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity

In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. The compounds were evaluated for their in vitro antimic...

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Bibliographic Details
Main Authors: Ahmet Özdemir, Mehlika Dilek Altıntop, Belgin Sever, Hülya Karaca Gençer, Handan Açelya Kapkaç, Özlem Atlı, Merve Baysal
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
antimicrobial activity
chalcone
cytotoxicity
furan
genotoxicity
pyrrole
Online Access:https://www.mdpi.com/1420-3049/22/12/2112

Internet

https://www.mdpi.com/1420-3049/22/12/2112

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