Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been found in about half of HCM patients, while the genetic etiology and pathogenesis remain unknown for many cases of HCM. To identify novel mec...

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Bibliographic Details
Main Authors: Yuta Higashikuse, Nishant Mittal, Takuro Arimura, Sung Han Yoon, Mayumi Oda, Hirokazu Enomoto, Ruri Kaneda, Fumiyuki Hattori, Takeshi Suzuki, Atsushi Kawakami, Alexander Gasch, Tetsushi Furukawa, Siegfried Labeit, Keiichi Fukuda, Akinori Kimura, Shinji Makino
Format: Article
Language:English
Published: The Company of Biologists 2019-11-01
Series:Disease Models & Mechanisms
Subjects:
genetics
familial hypertrophic cardiomyopathy
titin
ubiquitin
myocardial stiffness
Online Access:http://dmm.biologists.org/content/12/11/dmm041103

Internet

http://dmm.biologists.org/content/12/11/dmm041103

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