A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility

A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility

Abstract Background Identification and characterization of non-typeable Haemophilus influenzae (NTHi) with reduced susceptibility to β-lactam antibiotics due to mutations in penicillin binding protein 3 (PBP3) is a clinical challenge. We analyzed a blood isolate, NTHi93–57485, that was categorized a...

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Bibliographic Details
Main Authors: John Thegerström, Erika Matuschek, Yu-Ching Su, Kristian Riesbeck, Fredrik Resman
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Microbiology
Subjects:
Ampicillin - β-lactam resistance - ftsI - Haemophilus influenzae - PBP3 - penicillin binding proteins - site directed mutagenesis
Online Access:http://link.springer.com/article/10.1186/s12866-018-1196-6

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http://link.springer.com/article/10.1186/s12866-018-1196-6

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