S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking

Summary: Clinical severity of Staphylococcus aureus respiratory infection correlates with alpha toxin (AT) expression. AT activates the NLRP3 inflammasome; deletion of Nlrp3, or AT neutralization, protects mice from lethal S. aureus pneumonia. We tested the hypothesis that this protection is not due...

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Bibliographic Details
Main Authors: Taylor S. Cohen, Michelle L. Boland, Brandon B. Boland, Virginia Takahashi, Andrey Tovchigrechko, Young Lee, Aimee D. Wilde, Mark J. Mazaitis, Omari Jones-Nelson, Christine Tkaczyk, Rajiv Raja, C. Kendall Stover, Bret R. Sellman
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301955

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http://www.sciencedirect.com/science/article/pii/S2211124718301955

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