Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids

There is a strong association between hepatocyte phospholipid homeostasis and non-alcoholic fatty liver disease (NAFLD). The phosphatidylcholine to phosphatidylethanolamine ratio (PC/PE) often draws special attention as genetic and dietary disruptions to this ratio can provoke steatohepatitis and ot...

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Bibliographic Details
Main Authors: Kang-Yu Peng, Christopher K Barlow, Helene Kammoun, Natalie A Mellett, Jacquelyn M Weir, Andrew J Murphy, Mark A Febbraio, Peter J Meikle
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/11/3/188