Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial

Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial

Abstract Ibudilast, a neuroimmune modulator which selectively inhibits phosphodiesterases (PDE)-3, -4, -10, and -11, and macrophage migration inhibitory factor (MIF), shows promise as a novel pharmacotherapy for alcohol use disorder (AUD). However, the mechanisms of action underlying ibudilast’s eff...

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Bibliographic Details
Main Authors: Erica N. Grodin, Spencer Bujarski, Brandon Towns, Elizabeth Burnette, Steven Nieto, Aaron Lim, Johnny Lin, Karen Miotto, Artha Gillis, Michael R. Irwin, Christopher Evans, Lara A. Ray
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01478-5

Internet

https://doi.org/10.1038/s41398-021-01478-5

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