TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary Cryptococcosis

TNF-α-Producing Cryptococcus neoformans Exerts Protective Effects on Host Defenses in Murine Pulmonary Cryptococcosis

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic potential of TNF-α supplementation as a booster of host anti-cryptococcal responses, we engineered a C. neoformans s...

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Bibliographic Details
Main Authors: Zhenzong Fa, Jintao Xu, Jiu Yi, Junjun Sang, Weihua Pan, Qun Xie, Runping Yang, Wei Fang, Wanqing Liao, Michal A. Olszewski
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
cryptococcosis
TNF-α
host defense
TNF-α-producing C. neoformans
Th1/Th2 balance
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01725/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01725/full

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