IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice

IgG Subclass Determines Suppression Versus Enhancement of Humoral Alloimmunity to Kell RBC Antigens in Mice

It has long been appreciated that immunoglobulins are not just the effector endpoint of humoral immunity, but rather have a complex role in regulating antibody responses themselves. Donor derived anti-RhD IgG has been used for over 50 years as an immunoprophylactic to prevent maternal alloimmunizati...

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Bibliographic Details
Main Authors: Paurvi Shinde, Heather L. Howie, Tamara C. Stegmann, Ariel M. Hay, Hayley R. Waterman, Zoltan Szittner, Arthur E. H. Bentlage, Linda Kapp, Suzanne N. Lissenberg-Thunnissen, Gillian Dekkers, Richard B. M. Schasfoort, Sarah J. Ratcliffe, Mark E. Smolkin, Gestur Vidarsson, C. Ellen van der Schoot, Krystalyn E. Hudson, James C. Zimring
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
antibody
immune regulation
IgG subclass
red blood cell
alloimmunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01516/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01516/full

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