Stat6-dependent inhibition of Mincle expression in mouse and human antigen-presenting cells by the Th2 cytokine IL-4

Stat6-dependent inhibition of Mincle expression in mouse and human antigen-presenting cells by the Th2 cytokine IL-4

The C-type lectin receptors (CLR) Mincle, Mcl and Dectin-2 bind mycobacterial and fungal cell wall glycolipids and carbohydrates. Recently, we described that expression of these CLR is down-regulated during differentiation of human monocytes to dendritic cells (DC) in the presence of GM-CSF and IL-4...

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Bibliographic Details
Main Authors: Thomas Hupfer, Judith Schick, Katrin Jozefowski, David Voehringer, Jenny Ostrop, Roland Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Macrophages
Monocytes
dectin-1
C-type lectin receptor
Dendritic cells (DCs)
MCL
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00423/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00423/full

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