Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells

Lysosomes play a key role in regulating cell death in response to cancer therapies, yet little is known on the possible role of lysosomes in the therapeutic efficacy of G-quadruplex DNA ligands (G4L) in cancer cells. Here, we investigate the relationship between the modulation of lysosomal membrane...

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Bibliographic Details
Main Authors: Jennifer Beauvarlet, Rabindra Nath Das, Karla Alvarez-Valadez, Isabelle Martins, Alexandra Muller, Elodie Darbo, Elodie Richard, Pierre Soubeyran, Guido Kroemer, Jean Guillon, Jean-Louis Mergny, Mojgan Djavaheri-Mergny
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
Lysosome
lysosomal membrane permeabilization
cell death
cancer
G-quadruplex ligand
triarylpyridine compounds
Online Access:https://www.mdpi.com/2072-6694/12/6/1621

Internet

https://www.mdpi.com/2072-6694/12/6/1621

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