High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck.

High heregulin expression is associated with activated HER3 and may define an actionable biomarker in patients with squamous cell carcinomas of the head and neck.

PURPOSE:Tumors with oncogenic dependencies on the HER family of receptor tyrosine kinases (RTKs) often respond well to targeted inhibition. Our previous work suggested that many cell lines derived from squamous cell carcinomas of the head and neck (SCCHNs) depend on autocrine signaling driven by HER...

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Bibliographic Details
Main Authors: David S Shames, Juliet Carbon, Kim Walter, Adrian M Jubb, Cleopatra Kozlowski, Tom Januario, An Do, Ling Fu, Yuanyuan Xiao, Rajiv Raja, Brittany Jiang, Ashi Malekafzali, Howard Stern, Jeff Settleman, Timothy R Wilson, Garret M Hampton, Robert L Yauch, Andrea Pirzkall, Lukas C Amler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3586092?pdf=render

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http://europepmc.org/articles/PMC3586092?pdf=render

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