Limited Effect of Indolamine 2,3-Dioxygenase Expression and Enzymatic Activity on Lupus-Like Disease in B6.Nba2 Mice

Limited Effect of Indolamine 2,3-Dioxygenase Expression and Enzymatic Activity on Lupus-Like Disease in B6.Nba2 Mice

B6.Nba2 mice spontaneously develop a lupus-like disease characterized by elevated levels of serum anti-nuclear autoantibody (ANA) immune complexes and constitutive type I interferon (IFNα) production. During disease progression, both plasmacytoid dendritic cells (pDCs) and antibody secreting plasma...

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Bibliographic Details
Main Authors: Laura M. Davison, Jessica C. Liu, Lei Huang, Thomas M. Carroll, Andrew L. Mellor, Trine N. Jørgensen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
antibodies
autoimmunity
dendritic cells
rodent
immunization
systemic lupus erythematosus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02017/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02017/full

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