Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury

Sex-Dependent Pathology in the HPA Axis at a Sub-acute Period After Experimental Traumatic Brain Injury

Over 2.8 million traumatic brain injuries (TBIs) are reported in the United States annually, of which, over 75% are mild TBIs with diffuse axonal injury (DAI) as the primary pathology. TBI instigates a stress response that stimulates the hypothalamic-pituitary-adrenal (HPA) axis concurrently with DA...

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Bibliographic Details
Main Authors: Caitlin E. Bromberg, Andrew M. Condon, Samantha W. Ridgway, Gokul Krishna, Pamela C. Garcia-Filion, P. David Adelson, Rachel K. Rowe, Theresa Currier Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Neurology
Subjects:
hypothalamic-pituitary-adrenal axis
diffuse traumatic brain injury
sex-differences
glucocorticoid receptors
neuroinflammation
astrocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00946/full

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https://www.frontiersin.org/article/10.3389/fneur.2020.00946/full

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