Functional characterization of nuclear localization and export signals in hepatitis C virus proteins and their role in the membranous web.

The hepatitis C virus (HCV) is a positive strand RNA virus of the Flavivirus family that replicates in the cytoplasm of infected hepatocytes. Previously, several nuclear localization signals (NLS) and nuclear export signals (NES) have been identified in HCV proteins, however, there is little evidenc...

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Bibliographic Details
Main Authors: Aviad Levin, Christopher J Neufeldt, Daniel Pang, Kristen Wilson, Darci Loewen-Dobler, Michael A Joyce, Richard W Wozniak, D Lorne J Tyrrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4259358?pdf=render