The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.

The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.

Rai/ShcC is a member of the Shc family of protein adaptors expressed with the highest abundance in the central nervous system, where it exerts a protective function by coupling neurotrophic receptors to the PI3K/Akt survival pathway. Rai is also expressed, albeit at lower levels, in other cell types...

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Bibliographic Details
Main Authors: Micol Ferro, Maria Teresa Savino, Barbara Ortensi, Francesca Finetti, Luca Genovese, Giulia Masi, Cristina Ulivieri, Daniela Benati, Giuliana Pelicci, Cosima T Baldari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248456?pdf=render

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http://europepmc.org/articles/PMC3248456?pdf=render

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