Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Abstract Background Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T lymphocyte (CTL) responses in patients. Several peptide-based...

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Bibliographic Details
Main Authors: Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte, Scott H. Robbins
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Cancer vaccines
Synthetic long peptides (SLP)
Toll-like receptor 9 (TLR9)
Human papilloma virus antigen E7 (HPV E7)
Online Access:http://link.springer.com/article/10.1186/s12885-019-5725-y

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http://link.springer.com/article/10.1186/s12885-019-5725-y

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