Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G

Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G

(1) Background: Metallo-β-lactamases (MBLs) have raised concerns due to their ability to inactivate carbapenems and newer generation cephalosporins and the absence of clinically available MBL inhibitors. Their genes are often transferred horizontally, and the number of MBL variants has grow...

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Bibliographic Details
Main Authors: Charles J. Zhang, Mohammad Faheem, Paulie Dang, Monica N. Morris, Pooja Kumar, Peter Oelschlaeger
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Biomolecules
Subjects:
antibiotic resistance
β-lactamase
circular dichroism
thermal stability
zinc content
substrate spectrum
suppressor mutation
Online Access:https://www.mdpi.com/2218-273X/9/11/724

Internet

https://www.mdpi.com/2218-273X/9/11/724

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