The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation.

Mitochondrial fatty-acid beta-oxidation (mFAO) plays a central role in mammalian energy metabolism. Multiple severe diseases are associated with defects in this pathway. Its kinetic structure is characterized by a complex wiring of which the functional implications have hardly been explored. Repetit...

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Bibliographic Details
Main Authors: Anne-Claire M F Martines, Karen van Eunen, Dirk-Jan Reijngoud, Barbara M Bakker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC5397069?pdf=render