Testing biochemistry revisited: how in vivo metabolism can be understood from in vitro enzyme kinetics.

by Karen van Eunen, José A L Kiewiet, Hans V Westerhoff, Barbara M Bakker
Published 2012-01-01

The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation.

by Anne-Claire M F Martines, Karen van Eunen, Dirk-Jan Reijngoud, Barbara M Bakker
Published 2017-04-01

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

by Gijs den Besten, Karen van Eunen, Albert K. Groen, Koen Venema, Dirk-Jan Reijngoud, Barbara M. Bakker
Published 2013-09-01

The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome.

by Gijs den Besten, Rick Havinga, Aycha Bleeker, Shodhan Rao, Albert Gerding, Karen van Eunen, Albert K Groen, Dirk-Jan Reijngoud, Barbara M Bakker
Published 2014-01-01

Simultaneous Induction of Glycolysis and Oxidative Phosphorylation during Activation of Hepatic Stellate Cells Reveals Novel Mitochondrial Targets to Treat Liver Fibrosis

by Natalia Smith-Cortinez, Karen van Eunen, Janette Heegsma, Sandra Alejandra Serna-Salas, Svenja Sydor, Lars P. Bechmann, Han Moshage, Barbara M. Bakker, Klaas Nico Faber
Published 2020-11-01

Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1.

by Gijs den Besten, Albert Gerding, Theo H van Dijk, Jolita Ciapaite, Aycha Bleeker, Karen van Eunen, Rick Havinga, Albert K Groen, Dirk-Jan Reijngoud, Barbara M Bakker
Published 2015-01-01

Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload.

by Karen van Eunen, Sereh M J Simons, Albert Gerding, Aycha Bleeker, Gijs den Besten, Catharina M L Touw, Sander M Houten, Bert K Groen, Klaas Krab, Dirk-Jan Reijngoud, Barbara M Bakker
Published 2013-01-01

A systems study reveals concurrent activation of AMPK and mTOR by amino acids

by Piero Dalle Pezze, Stefanie Ruf, Annika G. Sonntag, Miriam Langelaar-Makkinje, Philip Hall, Alexander M. Heberle, Patricia Razquin Navas, Karen van Eunen, Regine C. Tölle, Jennifer J. Schwarz, Heike Wiese, Bettina Warscheid, Jana Deitersen, Björn Stork, Erik Fäßler, Sascha Schäuble, Udo Hahn, Peter Horvatovich, Daryl P. Shanley, Kathrin Thedieck
Published 2016-11-01