The promiscuous enzyme medium-chain 3-keto-acyl-CoA thiolase triggers a vicious cycle in fatty-acid beta-oxidation.
Mitochondrial fatty-acid beta-oxidation (mFAO) plays a central role in mammalian energy metabolism. Multiple severe diseases are associated with defects in this pathway. Its kinetic structure is characterized by a complex wiring of which the functional implications have hardly been explored. Repetit...
Main Authors: | Anne-Claire M F Martines, Karen van Eunen, Dirk-Jan Reijngoud, Barbara M Bakker |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-04-01
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Series: | PLoS Computational Biology |
Online Access: | http://europepmc.org/articles/PMC5397069?pdf=render |
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