Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

Abstract Background Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we found to disrupt highly conserved biophysical interact...

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Bibliographic Details
Main Authors: Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Summers, Lynne V. Abruzzo, Laura Rassenti, Thomas J. Kipps, Sameer Parikh, Neil E. Kay, Kerry A. Rogers, Jennifer A. Woyach, Vincenzo Coppola, Yuh Min Chook, Christopher Oakes, John C. Byrd, Rosa Lapalombella
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Hematology & Oncology
Subjects:
XPO1
Chronic lymphocytic leukemia
Mouse model
Selinexor
Sines
Expression profiling
Online Access:https://doi.org/10.1186/s13045-021-01032-2

Internet

https://doi.org/10.1186/s13045-021-01032-2

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