Regulation of PKC-θ function by phosphorylation in T-cell-receptor signaling

Regulation of PKC-θ function by phosphorylation in T-cell-receptor signaling

Protein kinase C (PKC)-θ is a serine/threonine kinase belonging to the calcium-independent novel PKC subfamily; its expression is restricted to certain tissues and cell types, including T cells. The signals delivered from T-cell receptor (TCR) and CD28 costimulatory molecules trigger PKC-θ catalytic...

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Bibliographic Details
Main Authors: Xiaohong eWang, Huai-Chia eChuang, Ju-Pi eLi, Tse-Hua eTan
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Immunology
Subjects:
NF-kappa B
Phosphorylation
PKC-θ
TCR signaling
GLK
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00197/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00197/full

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