Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

Metformin Attenuates Silica-Induced Pulmonary Fibrosis by Activating Autophagy via the AMPK-mTOR Signaling Pathway

Long-term exposure to crystalline silica particles leads to silicosis characterized by persistent inflammation and progressive fibrosis in the lung. So far, there is no specific treatment to cure the disease other than supportive care. In this study, we examined the effects of metformin, a prescribe...

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Bibliographic Details
Main Authors: Shu-xian Li, Chao Li, Xin-ru Pang, Juan Zhang, Gong-chang Yu, Abrey J. Yeo, Martin F. Lavin, Hua Shao, Qiang Jia, Cheng Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
silica
metformin
pulmonary fibrosis
AMPK-mTOR
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.719589/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.719589/full

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