PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction

PKB/SGK-Resistant GSK-3 Signaling Following Unilateral Ureteral Obstruction

Background/Aims: Renal tissue fibrosis contributes to the development of end-stage renal disease. Causes for renal tissue fibrosis include obstructive nephropathy. The development of renal fibrosis following unilateral ureteral obstruction (UUO) is blunted in gene-targeted mice lacking functional se...

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Bibliographic Details
Main Authors: Jakob Voelkl, Sobuj Mia, Adrian Meissner, Mohamed S. Ahmed, Martina Feger, Bernat Elvira, Britta Walker, Dario R. Alessi, Ioana Alesutan, Florian Lang
Format: Article
Language:English
Published: Karger Publishers 2014-03-01
Series:Kidney & Blood Pressure Research
Subjects:
Protein kinase B
Serum- and glucocorticoid-inducible kinase
Glycogen synthase kinase 3
Unilateral ureteral obstruction
β-catenin
Wnt
Renal fibrosis
Online Access:http://www.karger.com/Article/FullText/355763

Internet

http://www.karger.com/Article/FullText/355763

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