Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.

Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing.

BACKGROUND:Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarco...

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Main Authors: Alixe H M Kilgour, Iain J Gallagher, Alasdair M J MacLullich, Ruth Andrew, Calum D Gray, Philippa Hyde, Henning Wackerhage, Holger Husi, James A Ross, John M Starr, Karen E Chapman, Kenneth C H Fearon, Brian R Walker, Carolyn A Greig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3877148?pdf=render

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http://europepmc.org/articles/PMC3877148?pdf=render

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