Context-Specific BAFF-R Signaling by the NF-κB and PI3K Pathways

Context-Specific BAFF-R Signaling by the NF-κB and PI3K Pathways

BAFF is a soluble factor required for B cell maturation and survival. BAFF-R signals via the noncanonical NF-κB pathway regulated by the TRAF3/NIK/IKK1 axis. We show that deletion of Ikk1 during early B cell development causes a partial impairment in B cell maturation and BAFF-dependent survival, b...

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Bibliographic Details
Main Authors: Julia Jellusova, Ana V. Miletic, Matthew H. Cato, Wai-Wai Lin, Yinling Hu, Gail A. Bishop, Mark J. Shlomchik, Robert C. Rickert
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713006062

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http://www.sciencedirect.com/science/article/pii/S2211124713006062

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