Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

Designed Cell-Penetrating Peptide Inhibitors of Amyloid-beta Aggregation and Cytotoxicity

Summary: Amyloid proteins and peptides are a major contributing factor to the development of various neurodegenerative disorders, including Alzheimer’s and prion diseases. Previously, a designed cell-penetrating peptide (CPP) comprising a hydrophobic signal sequence followed by a prion protein (PrP)...

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Bibliographic Details
Main Authors: Anja Henning-Knechtel, Sunil Kumar, Cecilia Wallin, Sylwia Król, Sebastian K.T.S. Wärmländer, Jüri Jarvet, Gennaro Esposito, Serdal Kirmizialtin, Astrid Gräslund, Andrew D. Hamilton, Mazin Magzoub
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Cell Reports Physical Science
Subjects:
aggregation
Alzheimer’s disease
amyloid-beta peptide
cell-penetrating peptides
drug design
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2666386420300011

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http://www.sciencedirect.com/science/article/pii/S2666386420300011

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