Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity

Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4+ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (S...

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Bibliographic Details
Main Authors: Anne-Sophie Rousseau, Joseph Murdaca, Gwenaëlle Le Menn, Brigitte Sibille, Walter Wahli, Sébastien Le Garf, Giulia Chinetti, Jaap G. Neels, Isabelle Mothe-Satney
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Physiology
Subjects:
regulatory T cells
skeletal muscle
aging
immunometabolism
physical capacity
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.587753/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.587753/full

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