Invalidation of the Transcriptional Modulator of Lipid Metabolism PPARβ/δ in T Cells Prevents Age-Related Alteration of Body Composition and Loss of Endurance Capacity
Anti-inflammatory regulatory T cells (Tregs) are the most metabolically flexible CD4+ T cells by using both glycolysis and fatty acid oxidation (FAO) which allow them to migrate in tissues. With aging, Tregs accumulate in secondary lymphoid organs and are involved in impairment of skeletal muscle (S...
Main Authors: | Anne-Sophie Rousseau, Joseph Murdaca, Gwenaëlle Le Menn, Brigitte Sibille, Walter Wahli, Sébastien Le Garf, Giulia Chinetti, Jaap G. Neels, Isabelle Mothe-Satney |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-03-01
|
Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.587753/full |
Similar Items
-
Complementary Immunometabolic Effects of Exercise and PPARβ/δ Agonist in the Context of Diet-Induced Weight Loss in Obese Female Mice
by: Sébastien Le Garf, et al.
Published: (2019-10-01) -
Insights into the Role of PPARβ/δ in NAFLD
by: Jiapeng Chen, et al.
Published: (2018-06-01) -
PPARs Mediate Lipid Signaling in Inflammation and Cancer
by: Liliane Michalik, et al.
Published: (2008-01-01) -
The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance
by: David Aguilar-Recarte, et al.
Published: (2021-08-01) -
Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease
by: Montagner Alexandra, et al.
Published: (2013-02-01)