Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therapeutic benefits in some colorectal cancer patients

Bibliographic Details
Main Authors: Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05385-0

Internet

https://doi.org/10.1038/s41467-018-05385-0

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