Seeking the exclusive binding region of phenylalkylamine derivatives on human T‐type calcium channels via homology modeling and molecular dynamics simulation approach

Seeking the exclusive binding region of phenylalkylamine derivatives on human T‐type calcium channels via homology modeling and molecular dynamics simulation approach

Abstract Pharmaceutical features of phenylalkylamine derivatives (PAAs) binding to calcium channels have been studied extensively in the past decades. Only a few PAAs have the binding specificity on calcium channels, for example, NNC 55‐0396. Here, we created the homology models of human Cav3.2, Cav...

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Bibliographic Details
Main Authors: You Lu, Ming Li, Gi Young Lee, Na Zhao, Zhong Chen, Andrea Edwards, Kun Zhang
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Pharmacology Research & Perspectives
Subjects:
homology modeling
phenylalkylamine
selective binding
T‐type calcium channels
virtual drug screening
Online Access:https://doi.org/10.1002/prp2.783

Internet

https://doi.org/10.1002/prp2.783

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