Multifaceted Mechanisms of Cisplatin Resistance in Long-Term Treated Urothelial Carcinoma Cell Lines

Multifaceted Mechanisms of Cisplatin Resistance in Long-Term Treated Urothelial Carcinoma Cell Lines

Therapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cispl...

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Bibliographic Details
Main Authors: Margaretha A. Skowron, Margarita Melnikova, Joep G. H. van Roermund, Andrea Romano, Peter Albers, Jürgen Thomale, Wolfgang A. Schulz, Günter Niegisch, Michèle J. Hoffmann
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
urothelial carcinoma
cisplatin
resistance mechanisms
metallothionein
Survivin
YM155
Online Access:http://www.mdpi.com/1422-0067/19/2/590

Internet

http://www.mdpi.com/1422-0067/19/2/590

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