Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19

Summary: Epidemiological data showing increased severity and mortality of COVID-19 in men suggests a potential role for androgen in SARS-CoV-2 infection. Here, we present evidence for the transcriptional regulation of SARS-CoV-2 host cell receptor ACE2 and TMPRSS2 by androgen in mouse and human cell...

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Bibliographic Details
Main Authors: Qu Deng, Reyaz ur Rasool, Ronnie M. Russell, Ramakrishnan Natesan, Irfan A. Asangani
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:iScience
Subjects:
Biological Sciences
Molecular Biology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002224

Internet

http://www.sciencedirect.com/science/article/pii/S2589004221002224

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