Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

Sevoflurane Exposure Induces Neuronal Cell Parthanatos Initiated by DNA Damage in the Developing Brain via an Increase of Intracellular Reactive Oxygen Species

The safety of volatile anesthetics in infants and young children has been drawing increasing concern due to its potential neurotoxicity in the developing brain. Neuronal death is considered a major factor associated with developmental neurotoxicity after exposure to volatile anesthetics sevoflurane,...

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Bibliographic Details
Main Authors: Meihua Piao, Yingying Wang, Nan Liu, Xuedong Wang, Rui Chen, Jing Qin, Pengfei Ge, Chunsheng Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
sevoflurane
Parthanatos
DNA damage
oxidative stress
developing brain
neurotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.583782/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.583782/full

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