The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes

The Enigma of Substrate Recognition and Catalytic Efficiency of APE1-Like Enzymes

Despite significant achievements in the elucidation of the nature of protein-DNA contacts that control the specificity of nucleotide incision repair (NIR) by apurinic/apyrimidinic (AP) endonucleases, the question on how a given nucleotide is accommodated by the active site of the enzyme remains unan...

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Bibliographic Details
Main Authors: Anastasiia T. Davletgildeeva, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DNA repair
apurinic/apyrimidinic endonuclease
abasic site
target nucleotide recognition
pre-steady state kinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.617161/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.617161/full

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