A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

Orally administered drugs must overcome several barriers before reaching their target site. Such barriers depend largely upon specific membrane transport systems and intracellular drug-metabolizing enzymes. For the first time, the P-glycoprotein (P-gp) and cytochrome P450s, the main line of defense...

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Bibliographic Details
Main Authors: Jinyou Duan, Yang Ling, Yonghua Wang, Hua Yu, Chao Huang, Yan Li, Wuxia Zhang, Xue Xu
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
oral bioavailability
quantitative structure activity relationship
cytochrome P4503A4 and P4502D6
P-glycoprotein
Online Access:http://www.mdpi.com/1422-0067/13/6/6964

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http://www.mdpi.com/1422-0067/13/6/6964

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