Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ

The seipin gene (BSCL2) was originally identified in humans as a loss-of-function gene associated with congenital generalized lipodystrophy type 2 (CGL2). Neuronal seipin-knockout (seipin-nKO) mice display a depression-like phenotype with a reduced level of hippocampal peroxisome proliferator-activa...

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Bibliographic Details
Main Authors: Guoxi Li, Libin Zhou, Ying Zhu, Conghui Wang, Sha Sha, Xunde Xian, Yong Ji, George Liu, Ling Chen
Format: Article
Language:English
Published: The Company of Biologists 2015-12-01
Series:Disease Models & Mechanisms
Subjects:
Seipin
BSCL2
Neurogenesis
Peroxisome proliferator-activated receptor gamma (PPARγ)
Cell proliferation
Differentiation of progenitor cells
Online Access:http://dmm.biologists.org/content/8/12/1615

Internet

http://dmm.biologists.org/content/8/12/1615

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