Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization

Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of ex vivo cell-based gene therapy with stable expression of human pigment epithelium-derived factor (PEDF) release u...

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Bibliographic Details
Main Authors: Maria Hernandez, Sergio Recalde, Laura Garcia-Garcia, Jaione Bezunartea, Csaba Miskey, Sandra Johnen, Sabine Diarra, Attila Sebe, Juan Roberto Rodriguez-Madoz, Severine Pouillot, Corinne Marie, Zsuzsanna Izsvák, Daniel Scherman, Martina Kropp, Felipe Prosper, Gabriele Thumann, Zoltán Ivics, Alfredo Garcia-Layana, Patricia Fernandez-Robredo
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301214

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http://www.sciencedirect.com/science/article/pii/S2329050119301214

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