Patient-Derived Scaffolds of Colorectal Cancer Metastases as an Organotypic 3D Model of the Liver Metastatic Microenvironment

Patient-Derived Scaffolds of Colorectal Cancer Metastases as an Organotypic 3D Model of the Liver Metastatic Microenvironment

The liver is the most common site for colorectal cancer (CRC) metastasis and there is an urgent need for new tissue culture models to study colorectal cancer liver metastasis (CRLM) as current models do not mimic the biological, biochemical, and structural characteristics of the metastatic microenvi...

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Bibliographic Details
Main Authors: Edoardo D’Angelo, Dipa Natarajan, Francesca Sensi, Omolola Ajayi, Matteo Fassan, Enzo Mammano, Pierluigi Pilati, Piero Pavan, Silvia Bresolin, Melissa Preziosi, Rosa Miquel, Yoh Zen, Shilpa Chokshi, Krishna Menon, Nigel Heaton, Gaya Spolverato, Martina Piccoli, Roger Williams, Luca Urbani, Marco Agostini
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cancers
Subjects:
microenvironment
extracellular matrix
disease modeling
3d culture model
liver metastasis
decellularization
drug test
response to treatment
Online Access:https://www.mdpi.com/2072-6694/12/2/364

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https://www.mdpi.com/2072-6694/12/2/364

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