Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Inhibition of 5-Lipoxygenase in Hepatic Stellate Cells Alleviates Liver Fibrosis

Background and Purpose: Activation of hepatic stellate cells (HSC) is a central driver of liver fibrosis. 5-lipoxygenase (5-LO) is the key enzyme that catalyzes arachidonic acid into leukotrienes. In this study, we examined the role of 5-LO in HSC activation and liver fibrosis.Main Methods: Culture...

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Bibliographic Details
Main Authors: Shiyun Pu, Yanping Li, Qinhui Liu, Xu Zhang, Lei Chen, Rui Li, Jinhang Zhang, Tong Wu, Qin Tang, Xuping Yang, Zijing Zhang, Ya Huang, Jiangying Kuang, Hong Li, Min Zou, Wei Jiang, Jinhan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
non-alcoholic steatohepatitis
α-SMA
ERK
zileuton
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.628583/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.628583/full

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