Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice

Inhibition of Peptidyl Arginine Deiminase 4-Dependent Neutrophil Extracellular Trap Formation Reduces Angiotensin II-Induced Abdominal Aortic Aneurysm Rupture in Mice

Objective: Neutrophil infiltration plays an important role in the initiation and development of abdominal aortic aneurysm (AAA). Recent studies suggested that neutrophils could release neutrophil extracellular traps (NETs), leading to tissue injury in cardiovascular diseases. However, the role of NE...

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Bibliographic Details
Main Authors: Ming Wei, Xia Wang, Yanting Song, Di Zhu, Dan Qi, Shiyu Jiao, Guomin Xie, Ye Liu, Baoqi Yu, Jie Du, Yuji Wang, Aijuan Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
abdominal aortic aneurysm
neutrophil extracellular traps
vascular smooth muscle cells
apoptosis
peptidyl arginine deiminase 4
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.676612/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.676612/full

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