Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells.

BACKGROUND:High Mobility Group B (HMGB) proteins are nuclear architectural factors involved in chromatin remodeling and important nuclear events. HMGBs also play key roles outside the cell acting as alarmins or Damage-associated Molecular Patterns (DAMPs). In response to a danger signal these protei...

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Bibliographic Details
Main Authors: Pamela Cribb, Virginia Perdomo, Victoria L Alonso, Romina Manarin, Jorge Barrios-Payán, Brenda Marquina-Castillo, Luis Tavernelli, Rogelio Hernández-Pando
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5319819?pdf=render