Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling.

Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling.

BACKGROUND: The targeting of Ca(2+) cycling has emerged as a potential therapy for the treatment of severe heart failure. These approaches include gene therapy directed at overexpressing sarcoplasmic reticulum (SR) Ca(2+) ATPase, or ablation of phospholamban (PLN) and associated protein phosphatase...

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Main Authors: Yosuke Miyazaki, Yasuhiro Ikeda, Kozo Shiraishi, Shizuka N Fujimoto, Hidekazu Aoyama, Koichi Yoshimura, Makoto Inui, Masahiko Hoshijima, Hideko Kasahara, Hiroki Aoki, Masunori Matsuzaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338799?pdf=render

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http://europepmc.org/articles/PMC3338799?pdf=render

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