14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forks.

Replication fork integrity, which is essential for the maintenance of genome stability, is monitored by checkpoint-mediated phosphorylation events. 14-3-3 proteins are able to bind phosphorylated proteins and were shown to play an undefined role under DNA replication stress. Exonuclease 1 (Exo1) pro...

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Bibliographic Details
Main Authors: Kim Engels, Michele Giannattasio, Marco Muzi-Falconi, Massimo Lopes, Stefano Ferrari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3077382?pdf=render