Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require proteolytic processing for activation; however, the r...

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Bibliographic Details
Main Authors: Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Subjects:
IL-1 family
IL-36
protease
inflammation
IL-17
cathepsin G
elastase
neutrophil
psoriasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715015260

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http://www.sciencedirect.com/science/article/pii/S2211124715015260

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