The “Connection” Between HIV Drug Resistance and RNase H
Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcript...
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doaj-5d55f51a94c846dabcc84cbf0d6fa1632020-11-24T23:05:44ZengMDPI AGViruses1999-49152010-07-01271476150310.3390/v2071476The “Connection” Between HIV Drug Resistance and RNase HKrista A. Delviks-FrankenberryVinay K. PathakGalina N. NikolenkoCurrently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcriptase (RT), most genotypic analysis for drug resistance is limited to the first ~300 amino acids of RT. However, recent studies have demonstrated that mutations in the C-terminal domain of RT, specifically the connection subdomain and RNase H domain, can also increase resistance to both NRTIs and NNRTIs. In this review we will present the potential mechanisms by which mutations in the C-terminal domain of RT influence NRTI and NNRTI susceptibility, summarize the prevalence of the mutations in these regions of RT identified to date, and discuss their importance to clinical drug resistance. http://www.mdpi.com/1999-4915/2/7/1476/connection subdomainNRTINNRTIRNase Hdrug resistanceHIV |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Krista A. Delviks-Frankenberry Vinay K. Pathak Galina N. Nikolenko |
spellingShingle |
Krista A. Delviks-Frankenberry Vinay K. Pathak Galina N. Nikolenko The “Connection” Between HIV Drug Resistance and RNase H Viruses connection subdomain NRTI NNRTI RNase H drug resistance HIV |
author_facet |
Krista A. Delviks-Frankenberry Vinay K. Pathak Galina N. Nikolenko |
author_sort |
Krista A. Delviks-Frankenberry |
title |
The “Connection” Between HIV Drug Resistance and RNase H |
title_short |
The “Connection” Between HIV Drug Resistance and RNase H |
title_full |
The “Connection” Between HIV Drug Resistance and RNase H |
title_fullStr |
The “Connection” Between HIV Drug Resistance and RNase H |
title_full_unstemmed |
The “Connection” Between HIV Drug Resistance and RNase H |
title_sort |
“connection” between hiv drug resistance and rnase h |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2010-07-01 |
description |
Currently, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are two classes of antiretroviral agents that are approved for treatment of HIV-1 infection. Since both NRTIs and NNRTIs target the polymerase (pol) domain of reverse transcriptase (RT), most genotypic analysis for drug resistance is limited to the first ~300 amino acids of RT. However, recent studies have demonstrated that mutations in the C-terminal domain of RT, specifically the connection subdomain and RNase H domain, can also increase resistance to both NRTIs and NNRTIs. In this review we will present the potential mechanisms by which mutations in the C-terminal domain of RT influence NRTI and NNRTI susceptibility, summarize the prevalence of the mutations in these regions of RT identified to date, and discuss their importance to clinical drug resistance. |
topic |
connection subdomain NRTI NNRTI RNase H drug resistance HIV |
url |
http://www.mdpi.com/1999-4915/2/7/1476/ |
work_keys_str_mv |
AT kristaadelviksfrankenberry theconnectionbetweenhivdrugresistanceandrnaseh AT vinaykpathak theconnectionbetweenhivdrugresistanceandrnaseh AT galinannikolenko theconnectionbetweenhivdrugresistanceandrnaseh AT kristaadelviksfrankenberry connectionbetweenhivdrugresistanceandrnaseh AT vinaykpathak connectionbetweenhivdrugresistanceandrnaseh AT galinannikolenko connectionbetweenhivdrugresistanceandrnaseh |
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