Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation

Upregulation of leukocyte immunoglobulin-like receptor B4 on interstitial macrophages in COPD; their possible protective role against emphysema formation

Abstract Background Leukocyte immunoglobulin-like receptor B4 (LILRB4) is one of the inhibitory receptors in various types of immune cells including macrophages. Previous reports suggested that LILRB4 could be involved in a negative feedback system to prevent excessive inflammatory responses. Howeve...

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Bibliographic Details
Main Authors: Ayumi Mitsune, Mitsuhiro Yamada, Naoya Fujino, Tadahisa Numakura, Tomohiro Ichikawa, Ayumi Suzuki, Shuichiro Matsumoto, Yoshiya Mitsuhashi, Koji Itakura, Tomonori Makiguchi, Akira Koarai, Tsutomu Tamada, Shota Endo, Toshiyuki Takai, Yoshinori Okada, Satoshi Suzuki, Masakazu Ichinose, Hisatoshi Sugiura
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Respiratory Research
Subjects:
Pulmonary macrophage
Matrix metalloproteinase 12
Pulmonary emphysema
Online Access:https://doi.org/10.1186/s12931-021-01828-3

Internet

https://doi.org/10.1186/s12931-021-01828-3

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