Paroxysmal Nocturnal Hemoglobinuria (Membrane Defect, Pathogenesis, Aplastic Anemia, Diagnosis)
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal disorder in which intravascular hemolysis results from the somatic mutation of the totipotent stem cells causing an intrinsic defect in red cell membrane. PNH cells lack glycosylphosphatidylinositol (GPI) anchored membrane proteins. Of...
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| Format: | Article |
| Language: | English |
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Karolinum Press
2000-01-01
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| Series: | Acta Medica |
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| Online Access: | https://actamedica.lfhk.cuni.cz/43/1/0003/ |